{"id":1908,"date":"2023-02-24T14:26:10","date_gmt":"2023-02-24T05:26:10","guid":{"rendered":"https:\/\/www.gotoku.co.jp\/wordpress\/?page_id=1908"},"modified":"2025-05-28T14:24:43","modified_gmt":"2025-05-28T05:24:43","slug":"ecg505","status":"publish","type":"page","link":"https:\/\/www.gotoku.co.jp\/en\/ecg505\/","title":{"rendered":"E.C.G-505\u00ae"},"content":{"rendered":"\n

\"\" E.C.G-505\u00ae<\/sup><\/strong><\/h2>\n\n\n
\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t
Product Info<\/div>\n\t\t\t<\/div>
\n\t\t\t\t
Reference Data<\/div>\n\t\t\t<\/div><\/div>\n\t\t\t<\/div>\n\t\t\t
\n\n

What is E.C.G-505\u00ae<\/sup><\/span><\/strong><\/p>\n\n\n\n

E.C.G-505\u00ae<\/sup><\/span> (Carmellose Calcium) is a chemically modified cellulosic disintegrant containing a Ca chelate structure that confers water insolubility and hydration capacity.
It rapidly absorbs the water required for swelling, resulting in a good short disintegration time.
No organic solvents are used in the manufacturing process, so there is no need to worry about residual solvents.<\/span><\/p>\n\n\n\n

Basic Information<\/span><\/strong><\/p>\n\n\n\n

Product name: E.C.G-505\u00ae<\/sup>
Generic name: Carmellose Calcium
Packing style: 20kg slotted cardboard box (2-layer polyethylene inner bag)
Quality-assurance standards: Japanese Pharmacopoeia
\u3000\u3000\u3000\u3000Four (4) Pharmacopoeias\uff08JP\u30fbUSP-NF\u30fbEP\u30fbChP\uff09are available.
DMF Registration Number: US Registration No.030379
\u3000\u3000\u3000\u3000\u3000\u3000\u3000 China Registration No.F20180001742<\/span><\/p>\n\n\n\n

Acceptance Criteria<\/span><\/strong><\/p>\n\n\n\n

Parameters JP<\/th>Specifications JP<\/th>Ref. USP-NF<\/th>Ref. EP<\/th>Ref. ChP<\/th>Our test Method<\/th><\/tr><\/thead>
Description<\/strong><\/td><\/td><\/td><\/td><\/td><\/td><\/tr>
\u3000Appearance<\/td>a white to yellowish white powder<\/td>Meets specification<\/td>Meets specification<\/td>Meets specification<\/td>JP test method<\/td><\/tr>
\u3000pH
\u3000(1% suspension)<\/td>		between 4.5 and 6.0<\/td>4.5 - 6.0<\/td>\u2015<\/td>\u2015<\/td>Ditto<\/td><\/tr>
Identification<\/strong><\/td><\/td><\/td><\/td><\/td><\/td><\/tr>
\u3000Identification (1)<\/td>a red-purple color develops<\/td>Meets specification<\/td>Meets specification<\/td>Meets specification<\/td>Ditto<\/td><\/tr>
\u3000Identification (2)<\/td>a white, flocculent precipitate is produced<\/td>Meets specification<\/td>Meets specification<\/td>Meets specification<\/td>Ditto<\/td><\/tr>
\u3000Identification (3)<\/td>a brown, flocculent precipitate is produced<\/td>Meets specification<\/td>Meets specification<\/td>Meets specification<\/td>Ditto<\/td><\/tr>
\u3000Identification (4)<\/td>the solution responds to
the tests for calcium<\/td>		Meets specification<\/td>Meets specification<\/td>Meets specification<\/td>Ditto<\/td><\/tr>
Purity<\/strong><\/td><\/td><\/td><\/td><\/td><\/td><\/tr>
\u3000(1)\u00a0 Alkalinity<\/td>no red color develops<\/td>Meets specification<\/td>Meets specification<\/td>Meets specification<\/td>Ditto<\/td><\/tr>
\u3000(2)\u00a0 Chloride<\/td>not more than 0.36 %<\/td>\u22660.36 %<\/td>\u22660.36 %<\/td>\u22660.3 %<\/td>Ditto<\/td><\/tr>
\u3000(3)\u00a0 Sulfate<\/td>not more than 1.0 %<\/td>\u22661.0 %<\/td>\u22661.0%<\/td>\u22661.0 %<\/td>Ditto<\/td><\/tr>
Loss on drying<\/strong><\/td>not more than 10.0 %<\/td>\u226610.0 %<\/td>\u226610.0 %<\/td>\u226610.0 %<\/td>Ditto<\/td><\/tr>
Residue on ignition<\/strong><\/td>10.0 - 20.0 %<\/td>10.0 - 20.0 %<\/td>10.0 - 20.0 %<\/td>10.0 - 20.0 %<\/td>Ditto<\/td><\/tr>
Heavy metals\uff0a<\/strong><\/td>\u2015<\/td>\u2015<\/td>not more than 0.002%<\/td>Ditto<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\uff0aThere is no specification for \"Heavy metals in JP\/ Carmellose Calcium\", but \"Heavy metals in JP18\/ Carmellose Calcium\"
\u3000is conducted for the purpose of guaranteeing \"Heavy metals in ChP2020\/ Carboxymethlcellulose Calcium\".
\u3000Sulfuric acid is used in the manufacturing process.
\u3000Labeling : Regarding particle size , the weight ratio passing through 75\u00b5m is more than 95%.<\/p>\n\n\n\n

Rational and Molecular formula<\/span><\/strong><\/p>\n\n\n\n

Rational formula
\uff1a\uff3bC6<\/sub>H7<\/sub>O2<\/sub>(OH)3-X-Y<\/sub>(OCH2<\/sub>COO1\/2Ca)X<\/sub>(OCH2<\/sub>COOH)Y<\/sub>\uff3dn<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n<\/div>
\n\n

Average Particle Size\u30fbPowder Properties<\/span><\/strong><\/p>\n\n\n\n

Product Name<\/strong><\/td>Average Particle Size\u203b1<\/sup><\/strong><\/td>Powder Properties\u203b2<\/sup><\/strong><\/td><\/tr>
D10<\/sub>
\uff08\u03bcm\uff09<\/td>		D50<\/sub>
\uff08\u03bcm\uff09<\/td>		D90<\/sub>
\uff08\u03bcm\uff09<\/td>		Loose Bulk Density
\uff08g\/L\uff09<\/td>		Tap Density
\uff08g\/L\uff09<\/td>		Angle of Repose
\uff08degree\uff09<\/td><\/tr>
E.C.G-505<\/strong>\u00ae<\/strong><\/sup><\/span><\/td>20<\/td>52<\/td>114<\/td>474<\/td>651<\/td>44<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u3000\u3000\u203b1\u3000Reference value (laser diffraction type)
\u3000\u3000\u203b2\u3000Reference value<\/span><\/p>\n\n\n\n

SEM Image<\/strong><\/span><\/p>\n\n\n\n

\"\"<\/figure>\n\n<\/div><\/div>\n\t\t<\/div>\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

E.C.G-505\u00ae<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":1,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_monsterinsights_skip_tracking":false,"_locale":"en_US","_original_post":"https:\/\/www.gotoku.co.jp\/wordpress\/?page_id=1823","sns_share_botton_hide":"","vkExUnit_sns_title":"","_vk_print_noindex":"","sitemap_hide":"","vkExUnit_sitemap":"","_veu_custom_css":"h2 img {\r\n vertical-align: middle;\r\n}","veu_display_promotion_alert":"common","_exclude_from_list_pages":"","vkexunit_cta_each_option":"","vkExUnit_childPageIndex":"","vkExUnit_pageList_ancestor":"","vkExUnit_contact_enable":"","_lightning_design_setting":{"layout":"default"},"footnotes":""},"class_list":["post-1908","page","type-page","status-publish","hentry","en-US"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t