NS-300®
What is NS-300®
NS-300® (carmellose) is a cellulose-based disintegrant with excellent wicking properties.
NS-300® acts as a passageway for water and has the effect of allowing water to quickly permeate the inside of the formulation.
No organic solvents are used in the manufacturing process, so there is no need to worry about residual solvents.
Basic Information
Product name: NS-300®
Generic name: Carmellose
Packing style: 20kg slotted cardboard box (2-layer polyethylene inner bag)
Quality-assurance standards： Japanese Pharmacopoeia
Three(3) Pharmacopoeias（JP・USP-NF・EP）are available.
DMF Registration Number: US Registration No. 19767
China Registration No. F20180001743
Acceptance Criteria
| Parameters JP | Specifications JP | Ref. USP-NF | Ref. EP | Our test Method |
|---|---|---|---|---|
| Description | ||||
| Appearance | a white powder | Meets specification | JP test method | Ditto |
| Identification | ||||
| (1) Infrared absorption | compare the spectrum with the Reference Spectrum: both spectra exhibit similar intensities of absorption at the same wave numbers | Meets specification | Meets specification | Ditto |
| (2) pH (1% suspension) | between 3.5 and 5.0 | 3.5 - 5.0 | 33.5 - 5.0 | Ditto |
| Purity | ||||
| (1) Chlorides | not more than 0.36 % | ≦0.36% | ≦0.36% | Ditto |
| (2) Sulfates | not more than 0.72 % | ≦0.72% | ≦0.72% | Ditto |
| Loss on drying | not more than 8.0 % | ≦8.0% | ≦8.0% | Ditto |
| Residue on ignition | not more than 1.5 % | ≦1.5% | ≦1.5% | Ditto |
Rational and Molecular formula
Rational formula：
［C6H7O2(OH)3-X (OCH2COOH)X］n
Average Particle Size・Powder Properties
| Product Name | Average Particle Size※1 | Powder Properties※2 | ||||
| D10 （μm） | D50 （μm） | D90 （μm） | Loose Bulk Density （g/L） | Tap Density （g/L） | Angle of Repose （degree） | |
| NS-300® | 22 | 54 | 134 | 387 | 561 | 45 |
※1 Reference value (laser diffraction type)
※2 Reference value
SEM Image
